Studies on the isotetracenone antibiotics. IV. Hatomarubigins A, B, C and D, new isotetracenone antibiotics effective against multidrug-resistant tumor cells.
Open Access
- 1 January 1991
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 44 (11) , 1179-1186
- https://doi.org/10.7164/antibiotics.44.1179
Abstract
A complex of new isotetracenone group antibiotics was isolated from the cultured broth of Streptomyces sp. 2238-SVT4. It consisted of four related compounds, designated hatomarubigins A, B, C and D, whose structures were elucidated by NMR spectral analysis including a variety of 2D techniques. They enhanced the cytotoxicity of colchicine against multidrug-resistant tumor cells.Keywords
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