Role of Alveolar Macrophage‐ and Lung T Cell‐derived Mediators in Pulmonary Sarcoidosis
- 1 June 1986
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 465 (1) , 82-90
- https://doi.org/10.1111/j.1749-6632.1986.tb18483.x
Abstract
The process of granuloma formation in the lung is mediated by an intimate interaction between macrophages and T cells, and this interaction provides the appropriate environment for granuloma formation and the development of fibrosis. Much of this process of granuloma formation and fibrosis appears to be triggered by the release of immune mediators by alveolar macrophages and lung T cells.Keywords
This publication has 82 references indexed in Scilit:
- Interstitial Lung Disease: Concepts of PathogenesisSeminars in Respiratory and Critical Care Medicine, 1984
- Spontaneous Release of Interleukin-2 by Lung T Lymphocytes in Active Pulmonary SarcoidosisNew England Journal of Medicine, 1983
- Stimulation of Muscle Protein Degradation and Prostaglandin E2Release by Leukocytic Pyrogen (Interleukin-1)New England Journal of Medicine, 1983
- Pulmonary SarcoidosisNew England Journal of Medicine, 1981
- Regulation of the Immune Response — Role of the MacrophageNew England Journal of Medicine, 1980
- Cooperation between Mononuclear Phagocytes and Lymphocytes in ImmunityNew England Journal of Medicine, 1980
- Maintenance of Granuloma Formation in Pulmonary Sarcoidosis by T Lymphocytes within the LungNew England Journal of Medicine, 1980
- In vitro maturation of immature thymocytes into immunocompetent T cells in the absence of direct thymic influenceThe Journal of Experimental Medicine, 1978
- Resolution of a factor that enhances the antibody response of T cell-depleted murine splenocytes from several other monocyte productsCellular Immunology, 1976
- Stimulation of the release of a B cell-activating factor from human monocytesCellular Immunology, 1976