The kinetics of estrogen binding to rat α-fetoprotein
- 1 May 1984
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 40 (5) , 503-505
- https://doi.org/10.1007/bf01952408
Abstract
Fluid obtained from rat fetuses was utilized to characterize the affinity, number of binding sites, and the association and dissociation rate kinetics of the binding of estradiol and estrone to AFP. Statistical analysis demonstrated no differences when the values for the AFP-estradiol interaction were compared with those obtained for the AFP-estrone interaction. These data demonstrate that rat AFP specifically binds estradiol and estrone with a high capacity, high affinity, and similar binding kinetics.Keywords
This publication has 16 references indexed in Scilit:
- Binding Specificity of Rat a-Fetoprotein for a Series of Estrogen Derivatives: Studies Using Equilibrium and Nonequilibrium Binding Techniques*Endocrinology, 1979
- alpha-Fetoprotein is not a component of the estradiol receptor of the rat uterus.Proceedings of the National Academy of Sciences, 1977
- Isolation of two forms of rat alpha-fetoprotein and comparison of their binding parameters with estradiol-17βBiochimica et Biophysica Acta (BBA) - Protein Structure, 1975
- Characterization of the interaction between 17β-estradiol and its cytoplasmic receptor in the rat anterior pituitary glandBiochemistry, 1974
- Comparative study on the binding of estrogens by human and rat serum proteins in developmentBiochemical and Biophysical Research Communications, 1974
- Binding of estrogens by α-fetoprotein in rat amniotic fluidBiochimica et Biophysica Acta (BBA) - General Subjects, 1974
- Mathematics of Hormone-Receptor InteractionPublished by Springer Nature ,1973
- Estrogen-binding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methodsBiochemical and Biophysical Research Communications, 1972
- Unique Estrogen-Binding Properties of Rat Pregnancy PlasmaEndocrinology, 1971
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949