Strain distribution and linkage relationship of a mouse embryonic hemoglobin variant

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Abstract
Search for structural variants of three globin chains (x, y, z), synthesized only during mouse embryonic hematopoiesis, was carried out by electrophoretic analysis of blood from 12-day embryos, all with C57BL/6 mothers, and fathers from 115 inbred stocks selected for their diverse genetic origins. Structure of the β-chains of adult hemoglobins differed among the tested strains, with 57 carrying the Hbb sallele, 56 the Hbb dallele, and two the Hbb pallele. The search revealed no x- or z-chain variants but confirmed and extended knowledge of a previously described y-chain variant. Blood of all embryos sired by males from the 57 Hbb sstrains contained only y1-chains, while blood of all embryos sired by Hbb dor Hbb pmales contained y2-chains as well as the y1-chains inherited from their C57 BL/6 mother. The locus controlling structure of the y-chain of mouse embryonic hemoglobins is thus extremely closely linked to the locus controlling structure of adult hemoglobin β-chain, with maximum possible recombination frequency less than 0.019.