I. Single oral doses of 10 and 30 mg. of Na pregnandiol glucuronide were given 6 healthy [male][male] and their urinary excretion of this compound studied by the method of Venning. Within 3-5 days most subjects excreted in the urine from 30%-50% of the substance ingested. One subject failed to excrete any of the pregnandiol-complex. Gastro-intestinal absorption and renal filtration of this compound are discussed. II. Intramusc. injs. of progesterone in oil, which varied as to frequency and amt. from single injs. of 20 mg. to 4 daily injs. of 10 to 30 mg., were given 6 healthy [male][male] without any untoward symptoms. Urinary titrations following these treatments were made by Venning''s method for Na pregnandiol glucuronide. Amts. of the pregnandiol-complex, which ranged from 0% to 42.5% of the calculated theoretical yield, were recovered. Marked variations were observed to occur in the time of final disappearance of the pregnandiol-complex from the urine in relation to the last inj. Factors involved in the metabolism of progesterone by [male][male] are discussed. Possible applications of these data to problems of gynecic physiology and gynecologic therapy are suggested.