Studies on the Mechanism of Lymphocyte-Mediated Cytolysis
Open Access
- 1 August 1973
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 111 (2) , 389-394
- https://doi.org/10.4049/jimmunol.111.2.389
Abstract
The inhibition of thymus-derived lymphocyte-mediated cytolysis by histamine has been studied in a cytolytic system with immune C57BL/6 effector cells and DBA/2 mastocytoma target cells. Histamine inhibited cytolysis in a reversible manner, and stimulated intracellular cyclic AMP levels in the effector cell. Histamine inhibition was specifically antagonized by burimamide but not by other antihistamines, such as diphenhydramine. The specificity of this antagonism suggests that the histamine receptor on effector thymus-derived cells is of the histamine2 type only.Keywords
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