A Facile and Modular Synthesis of Phosphinooxazoline Ligands
- 31 May 2007
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (13) , 2529-2531
- https://doi.org/10.1021/ol070884s
Abstract
The copper(I) iodide catalyzed phosphine/aryl halide coupling procedure of Buchwald et al. provides modular, robust, and scaleable access to phosphinooxazoline (PHOX) ligands. The advantages of this method are highlighted by the convenient synthesis of PHOX ligands with varied steric and electronic properties, which would be challenging to synthesize by other protocols.Keywords
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