ANTICANCER AGENTS ADSORBED BY ACTIVATED CARBON PARTICLES, A NEW FORM OF DOSAGE ENHANCING EFFICACY ON LYMPH-NODAL METASTASES

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  • 1 September 1986
    • journal article
    • research article
    • Vol. 6  (5) , 1005-1008
Abstract
A new dosage form consisting of small activated carbon particles which adsorb Aclacinomycin A, Adriamycin, Mitomycin C or Pepleomycin was prepared in order to deliver larger amounts of anticancer agents to the lymph nodes through the high ability of lymphatics to adsorb particles. Animal experiments showed that: (A) The LD50 values of the new dosage form were higher than those of the dosage in solution. (B) The concentration of agents in lymph nodes was maintained at a higher level in the new dosage form than in solution form. (C) Clinically 33% of lymphnodal metastatic lesions became degenerative or inflammatory after a single administration.

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