AIDS Related Non-Hodgkin's Lymphoma of the Paranasal Sinuses

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Abstract
Non-Hodgkin's Lymphoma (NHL) is an established early manifestation of Autoimmune Deficiency Syndrome (AIDS). It is estimated that up to 10% of HIV+ patients will eventually acquire NHL. These lymphomas differ from those occurring in the general population with regard to natural history, histopathology, location, and therapeutic response. A review of the literature demonstrates only two previously reported cases of NHL originating in the paranasal sinuses in AIDS patients. We present four cases of AIDS-related NHL of the paranasal sinuses diagnosed at our institutions. Clinical and histopathological manifestations and modes of treatment are discussed. NHL must be considered in the differential diagnosis of HIV+ patients presenting with paranasal sinus pathology.