ROLE OF GASTRIC-EMPTYING ON ETHANOL POISONING IN RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 56  (1) , 37-41
Abstract
Glucose i.p. significantly inhibited the absorption of ethanol (2 g/kg) administered orally to rats. The effect was due to slowed emptying of the stomach, verified by analysis of the stomach contents and of blood ethanol levels. The rate of stomach emptying is inversely related to the blood glucose level. When glucose was given i.v. 15 min after oral administration of a lethal dose of ethanol (12.5 g/kg) no significant inhibition of ethanol absorption could be observed. I.v. propantheline, pyrithioxine and methylene blue were also unable to prolong the survival time or to influence the lethal blood ethanol concentration (about 170 mmol/l) of the ethanol-poisoned rats.

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