Electrocardiographic and hemodynamic effects of tocainide (W-36095) in man
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 14 (1) , 15-19
- https://doi.org/10.1007/bf00560253
Abstract
Tocainide is a new antiarrhythmic drug with a chemical structure related to that of lidocaine. In the present study, healthy volunteers were investigated after infusion of tocainide 450 mg over 45 min. In nine subjects His bundle electrograms, sinus recovery time and ventricular effective refractory periods were recorded. No major changes were seen. In eight cases the hemodynamic effects at rest and during exercise were studied. No significant circulatory effects were observed. No clinically important side-effects were noted.Keywords
This publication has 6 references indexed in Scilit:
- Clinical efficacy and pharmacokinetics of a new orally effective antiarrhythmic, tocainide.Circulation, 1976
- The effect of therapeutic doses of lidocaine hydrochloride on the effective refractory period of the right ventricle in manCardiovascular Research, 1975
- Electrophysiological effects of the antiarrhythmic agent QX-572 in the human heart with special reference to rate-induced changes in effective refractory periodsCardiovascular Research, 1975
- Lidocaine in the Prevention of Primary Ventricular FibrillationNew England Journal of Medicine, 1974
- Antiarrhythmic and circulatory effects of astra W36095: A new lidocaine-like agentThe American Journal of Cardiology, 1974
- Catheter Technique for Recording His Bundle Activity in ManCirculation, 1969