On the mechanism of action of griseofulvin in dermatophytosis

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Abstract
Guinea pig hair absorbed or adsorbed with griseofulvin was less efficiently hydrolyzed by the extracellular and cell-bound keratinases of Trichophyton mentagrophytes than untreated control hair. The same observations were made using hair from guinea pigs treated orally with griseofulvin. This antibiotic and 3 related compounds had no effect on the active sites of the keratinases. The results of these studies support the hypothesis that resistance to dermatophytic attack is the result of griseofulvin incorporation into keratinous structures causing substrate modification.