Abstract PO-159: Mediation of black/white race disparity in triple-negative breast cancer: Effect of type 2 diabetes mellitus

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It is theorized that the black/white race disparity in aggressive breast cancer (BC) subtype might be transmitted through social and reproductive influences. Recent studies suggest that type 2 diabetes mellitus (diabetes) may also contribute to the disparity but the role of diabetes is unclear and in need of further study. Hence, we examined to what extent the black/white race disparity in triple-negative (TN) BC might be transmitted through these influences. Our study sample is a previously reported historical cohort of 419 consecutively enrolled (331 non-Hispanic black (nHB) and 88 nH white (nHW)) women with primary BC aged 24-94 years, treated between 2000-2005 at an NCI-MBCCOP facility in Chicago, IL (Dookeran et al. 2012). US 2000 census ZIP Code Tabulation Area (ZCTA) data matched to patient address zip codes at diagnosis was used to develop a single binary measure of socioeconomic position (SEP) (> US poverty mean vs. referent of US poverty mean Citation Format: Keith A. Dookeran. Mediation of black/white race disparity in triple-negative breast cancer: Effect of type 2 diabetes mellitus [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-159.

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