Susceptibility to adjuvant arthritis: relative importance of adrenal activity and bacterial flora
Open Access
- 1 July 1994
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 97 (1) , 33-38
- https://doi.org/10.1111/j.1365-2249.1994.tb06575.x
Abstract
SUMMARY: Previous studies on the regulation of bacterial-induced arthritis in rats have focused on endocrine aspects as well as differences in T cell immunity against bacterial epitopes. We analysed the role of both adrenal activity and bacterial flora in determining susceptibility to bacterial-induced arthritis. Outbred Wistar rats show a low incidence of adjuvant arthritis. Moderate sensitivity to adjuvant arthritis was found in a selected., stress-resist ant line of the Wistar rat, whereas no arthritis was found in a stress-susceptible Wistar line. Plasma corticosterone responses after IL-1α exposure were, however, identical in these two lines, excluding a direct correlation between susceptibility and corticosterone levels. In line with previous findings in germ-free (GF) F344 rats, GE Wistars also appeared highly susceptible to arthritis. We further analysed the corticosterone responses in GE and conventional (CV) rats. Administration of IL-1α induced identical corticosterone responses in both CV and GF E344 rats. In addition, plasma corticosterone levels were measured around the time of onset of arthritis. Whereas no rise was seen in the arthritis-resistant CV rats, a significant increase was observed from day 14 in GE rats, at the moment of onset of arthritis. Although this corticosterone response was insufficient to prevent arthritis, it may have ameliorated disease expression in the GK F344 rats. Our data indicate that the bacterial flora, and therefore T cell tolerance, is of prime importance in determining susceptibility, whereas the activity of the hypothalamus-pituitary-adrenal (HPA) axis may modulate disease severity.Keywords
This publication has 19 references indexed in Scilit:
- Regulation of resistance against adjuvant arthritis in the Fisher ratClinical and Experimental Immunology, 1993
- Temporal covariation of soluble interleukin‐2 receptor levels, daily stress, and disease activity in rheumatoid arthritisArthritis & Rheumatism, 1993
- Psychoimmunology and Rheumatoid Arthritis: Concepts and MethodologiesThe International Journal of Psychiatry in Medicine, 1990
- Stress, emotion, and human immune function.Psychological Bulletin, 1990
- Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids.The Journal of Experimental Medicine, 1989
- T cell responses to streptococcal antigens in rats: Relation to susceptibility to streptococcal cell wall-induced arthritisCellular Immunology, 1988
- Suppressive effect of Escherichia coli on adjuvant‐induced arthritis in germ‐free ratsArthritis & Rheumatism, 1986
- Susceptibility to adjuvant arthritis in da and F344 RATS. A dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complexArthritis & Rheumatism, 1982
- STRAIN and sex variation in the susceptibility to streptococcal CELL WALL–INDUCED POLYARTHRITIS IN THE RATArthritis & Rheumatism, 1982
- Arthritis in rats after systemic injection of streptococcal cells or cell walls.The Journal of Experimental Medicine, 1977