Inactivation of Some Animal Viruses with Gamma Radiation from Cobalt-60.

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Abstract
Studies were undertaken to investigate the effect of gamma radiation on 4 animal viruses in vitro. The Lansing poliomyelitis virus was selected as representative of a small virus, St. Louis encephalitis and Western equine encephalomyelitis viruses were chosen to represent medium sized viruses and vaccinia a large virus. Gamma radiation from Co-60 proved to be an effective method for the inactivation of all viruses tested. Partially purified suspensions of the viruses used were more vulnerable to the lethal effects of gamma radiation than were crude suspensions. In crude and partially purified suspensions the smaller viruses required larger doses of gamma radiation for inactivation than did the larger viruses. The rate of inactivation for the viruses tested, within error of the experiment, was an exponential function of the dosage of gamma radiation.

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