A Randomized Trial of Cadexomer Iodine in Decubitus Ulcers

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Abstract
Patients (34) with decubitus ulcers were studied in a randomized trial to compare topical cadexomer iodine with the standard decubitus ulcer treatments used in the participating hospitals. There was a significant reduction of ulcer area with both treatments within 3 wk: 8 of 16 patients treated with cadexomer iodine had a reduction of ulcer area of > 50% compared with 1 of 18 patients treated with the standard treatment (P < 0.01). Patients (27) continued the same treatment for 5 more wk, during which time 6 in the cadexomer iodine group healed, compared with 1 in the standard treatment group (P < 0.05). Cadexomer iodine was superior to the standard treatment in removing pus and debris from the ulcer surface and in reducing pain at the ulcer site. It was easy to apply and to remove from the ulcers and did not stain skin or clothing. Transient smarting during the 1st h after application was reported by 3 patients, and 1 patient complained of skin irritation. Cadexomer iodine applied daily has a debriding effect on decubitus ulcers and accelerates healing.

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