Association of Vesiculobullous Eruptions with Mycosis fungoides

Abstract
Mycosis fungoides (MF) is, on extremely rare occasions, associated with vesiculobullous eruptions. This report describes clinical, histological and immunohistochemical findings of a case of MF with vesiculobullous lesions. Characteristic features of our case included: (a) bullous lesions evolving rapidly in 12–24 h with severe itch on erythematous and normal-appearing skin; (b) a positive Nikolsky sign; (c) an intraepidermal blister; (d) direct and indirect immunofluorescence stainings were all negative with IgG, IgA, IgM and C3, and (e) atypical lymphocytes in the infiltrates were of helper/inducer T cell type.

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