RELATIONSHIP OF MITOSIS TO ALVEOLAR DEVELOPMENT IN THE RAT MAMMARY GLAND

1 July 1971

journal article
Published by Bioscientifica in Journal of Endocrinology

Vol. 50 (3) , 501-505
https://doi.org/10.1677/joe.0.0500501

Abstract

After 3 and 5 days of culture of whole rat mammary glands in the presence of insulin, or insulin plus prolactin, or insulin plus prolactin plus aldosterone, or insulin plus prolactin plus oestradiol plus progesterone, there was good correlation between the levels of alveolar development and the [³H]thymidine labelling indices. Blockage of mitosis in explants developing in medium containing insulin plus prolactin also blocked alveolar development. Alveolar development is therefore proportional to and dependent on mitotic activity in the proper hormonal environment.

Keywords

INSULIN
MITOSIS
RAT
OESTRADIOL
MAMMARY
GLANDS
MITOTIC
BLOCKED
ALVEOLAR DEVELOPMENT

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