Thromboplastic Studies on Hemophilia
- 29 March 1946
- journal article
- letter
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 103 (2674) , 402
- https://doi.org/10.1126/science.103.2674.402-a
Abstract
Moldavsky''s findings (Science, 1945, 102, 38-40) that injns. of penicillin in man caused decrease in blood coagulation time were confirmed. Using Howell''s coagulation time method, injn. of 2,000-5,000 units of penicillin in rabbits and cats was also found to shorten coagulation time. Intramusc. injns. into 2 hemophiliac subjects caused no shortening of coagulation time, but shortening was produced by x-rays from a 200 KV machine operating on 20 M.A. at 50 cm. with a 2 mm. Cu filter. The blood was exposed in vitro to 60-80 r and it clotted in 1/2 to 1/3 the original time. The venom of Russell''s viper and of the S. American viper in vitro in concs. of 1:100,000 to 1:200,000 clotted hemophiliac blood in 5 mins.This publication has 1 reference indexed in Scilit: