The Effect of β Blockers on Total Peripheral Resistance
- 1 January 1986
- journal article
- review article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 8 (Supplement) , S49-S60
- https://doi.org/10.1097/00005344-198608004-00011
Abstract
A review of the relevant literature indicates that the effects of beta blockers on cardiac output and plasma renin or penetration of these drugs into the brain and cerebrospinal fluid are not essential for their antihypertensive effect. Reduction in blood pressure during long-term beta-blocker therapy is always associated with reduction of total peripheral resistance. Evidence is presented suggesting that blockade of presynaptic beta receptors underlies this vasodilator effect of beta blockers.Keywords
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