Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.
Open Access
- 1 September 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 133 (3) , 1339-1345
- https://doi.org/10.4049/jimmunol.133.3.1339
Abstract
By using as an experimental system the induction of growth of a cloned, antigen:Ia-reactive helper T cell line by an antigen receptor-specific monoclonal antibody, we demonstrated that growth requires two essential co-factors, exogenously produced IL 1 and endogenously produced IL 2. The primary role of the IL 1 is in the expression of receptors on the T cell surface for IL 2, rather than for promoting the synthesis of IL 2. The use of a clone-specific activating monoclonal antibody at nanogram amounts to activate a cloned helper T cell should allow a detailed characterization of T cell activation via antigen receptor cross-linking.This publication has 1 reference indexed in Scilit:
- T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation.Proceedings of the National Academy of Sciences, 1981