Antiviral agents of plant origin. II. Antiviral activity of scopadulcic acid B derivatives.
- 31 December 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (1) , 239-242
- https://doi.org/10.1248/cpb.38.239
Abstract
Scopadulcic acid B derivatives were synthesized and their antiviral activities against herpes simplex virus type 1 (HSV-1) were examined. All the derivatives synthesized showed lower inhibitory activities against HSV-1 than scopadulcic acid B (2). Five compounds, 7, 8, 15, 16, and 18, however, had in vitro therapeutic indexes larger than 7 and were considered to merit further investigation.This publication has 3 references indexed in Scilit:
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- Aphidicolin: A specific inhibitor of DNA polymerases in the cytosol of rat liverBiochemical and Biophysical Research Communications, 1978
- The Submerged Culture of Mammalian Cells: The Spinner CultureThe Journal of Immunology, 1957