Vagal Influence on Serotonin Concentration in Enterochromaffin Cells in the Cat

Publisher Website
Google Scholar
Abstract
The intracellular concentrations of 5‐HT in enterochromaffin cells of the jejunum, midgut and ileum of the cat have been estimated by a cytofluorimetric method before and after various periods of peripheral vagal nerve stimulation. The fluorescence intensities in randomized cell samples were measured photometrically after a standard illumination time before and after nerve stimulation. A significant decrease in 5‐HT concentration in the enterochromaffin cells all through the small intestine could be demonstrated, which is in support of the hypothesis of a neurogenic release of 5‐HT from enterochromaffin cells, possibly caused by vagal adrenergic fibres.