Clinical Progression of Giant-Axonal Neuropathy over a Twelve Year Period

Abstract
Giant-axonal neuropathy (GAN), a chronic peripheral neuropathy with associated CNS dysfunction and tight curly hair, is described in a 17 yr old girl. Biopsies of this girl''s muscle and nerve are characteristic of this condition. Her clinical course over a 12 yr period characterizes a disease of a slowly progressive nature.

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