Efficacy of Intravenous Immunoglobulin in Primary Humoral Immunodeficiency Disease

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Abstract
Twenty-one patients with primary humoral immunodeficiency were treated for 1 yr with a chemically intact Ig, 300 mg/kg body wt given i.v. every 3 wk, to compare Ig levels and clinical status with results achieved after standard tretment with i.m. Ig given previously for 1 yr. A substantial reduction of specific acute illnesses and antibiotic use was found for 18 of the 21 patients, particularly during the second 6 mo. of treatment. Average IgG levels before i.v. infusion were increased 243 mg/dl over previous i.m. pre-injection levels. Adverse effects were recorded for 2.5% of infusions.