Increased skin lactate in complex regional pain syndrome: Evidence for tissue hypoxia?
- 24 October 2000
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 55 (8) , 1213-1215
- https://doi.org/10.1212/wnl.55.8.1213
Abstract
Article abstract To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia.Keywords
This publication has 8 references indexed in Scilit:
- Experimental tissue acidosis leads to increased pain in complex regional pain syndrome (CRPS)Pain, 2000
- Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trialThe Lancet, 1999
- Patterns of hyperalgesia in complex regional pain syndromePain, 1999
- Complex regional pain syndrome type I (RSD)Neurology, 1998
- Reflex sympathetic dystrophy: changing concepts and taxonomyPain, 1995
- Reflex sympathetic dystrophy: evolution of microcirculatory disturbances in timePain, 1995
- Metabolic changes in reflex sympathetic dystrophy: A 31P NMR spectroscopy studyMuscle & Nerve, 1993
- Metabolic Effects of Prolonged Sympathetic Nerve Stimulation in Canine Subcutaneous Adipose TissueActa Physiologica Scandinavica, 1970