Effect of Oral Administration of Sulfanilylguanidine on Experimental Bacillary Dysentery in Isolated Loops of Colon of Macaca Mulatta and its Effect when Introduced into the Loops

Publisher Website
Google Scholar
Abstract
Isolated segments of colon in 5 monkeys (M. mulatta) were inoculated with a strain of Bact. dysenteriae (Flexner). An infection was produced in 2 monkeys with isolated pouches composed of cecum, ascending colon and part of the transverse colon. Oral administration of 1 gm. of sulfanilylguanidine daily for 6 days did not shorten the course of the disease in the 2 monkeys, although the organisms were not recovered after the drug was administered. In the 3 monkeys with isolated segments of transverse colon no dysentery was produced. One of these monkeys developed intermittent loose stools over a period of 2 months following the experiments and in 1 out of 6 trials Bact. dysenteriae was cultured. When sulfanilylguanidine was placed in the isolated segments of bowel there was a decrease in the number of gram-negative bacteria and an increase in the gram-positive organisms.