In Situ Recycling of Chiral Ligand and Surplus Nucleophile for a Noncatalytic Reaction: Amplification of Process Throughput in the Asymmetric Addition Step of Efavirenz (DMP 266)
- 14 March 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Process Research & Development
- Vol. 7 (3) , 324-328
- https://doi.org/10.1021/op025595s
Abstract
No abstract availableKeywords
This publication has 8 references indexed in Scilit:
- Solution Structures and Reactivities of the Mixed Aggregates Derived from n-Butyllithium and Vicinal Amino AlkoxidesJournal of the American Chemical Society, 2001
- Highly Enantioselective 1,2-Addition of Lithium Acetylide-Ephedrate Complexes: Spectroscopic Evidence for Reaction Proceeding via a 2:2 Tetramer, and X-ray Characterization of Related ComplexesJournal of the American Chemical Society, 2000
- Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase InhibitorThe Journal of Organic Chemistry, 1998
- Lithium Ephedrate-Mediated Addition of a Lithium Acetylide to a Ketone: Solution Structures and Relative Reactivities of Mixed Aggregates Underlying the High EnantioselectivitiesJournal of the American Chemical Society, 1998
- Highly Enantioselective Catalytic Asymmetric Automultiplication of Chiral Pyrimidyl AlcoholJournal of the American Chemical Society, 1996
- Use of an ephedrine alkoxide to mediate enantioselective addition of an acetylide to a prochiral ketone: asymmetric synthesis of the reverse transcriptase inhibitor L-743,726Tetrahedron Letters, 1995
- L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptaseAntimicrobial Agents and Chemotherapy, 1995
- Chiral N,N-dialkylnorephedrines as catalysts of the highly enantioselective addition of dialkylzincs to aliphatic and aromatic aldehydes. The asymmetric synthesis of secondary aliphatic and aromatic alcohols of high optical purityThe Journal of Organic Chemistry, 1991