DEGENERATIVE CHANGES IN CEREBRAL ARTERIES FOLLOWING ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE

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Abstract
The case of a young boy with Addison''s disease is described who was successfully treated for a period of 2 years with desoxycorticosterone acetate and small amts. of NaCl. During a crisis precipitated by an acute upper respiratory infection he received excessive amts. of cortical extract, desoxycorticosterone acetate and NaCl for 5 days and he died from overdosage of these agents following several convulsive seizures. At the autopsy, degenerative lesions were found in the cerebral arteries, while other arteries studied failed to reveal any changes except some degenerative changes in the atrophic suprarenal tissue. It was believed that the cerebral vascular lesions were due to the admn. of the hormone in moderate therapeutic doses over a long period of time. Admn. of desoxycorticosterone acetate to animals (dogs, rats, and rabbits) produced similar but not identical lesions of the cerebral blood vessels.

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