Successful treatment of SAPHO syndrome with infliximab: report of two cases

Abstract
In view of this information we treated two patients affected by refractory SAPHO syndrome with infliximab. Both patients had chest pain limiting normal activity despite adequate treatment with NSAIDs and second line treatment was unsuccessful. Both patients received three intravenous infusions of infliximab (5 mg/kg) at weeks 0, 2, and 6 and were evaluated at baseline, on days 3, 7, and 14, and then every two weeks.