Immunohistochemical Localization of Testosterone-Estradiol-Binding Globulin in a Clinically Hormone-Independent Prostatic Carcinoma
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Urologia Internationalis
- Vol. 38 (1) , 16-18
- https://doi.org/10.1159/000280854
Abstract
Localization of the testosterone-estradiol-binding globulin (TeBG) in prostate, liver and metastatic lymph node cells of a patient with hormone-independent prostatic carcinoma was studied by the triple-layer indirect immunoperoxidase method using anti-human TeBG antibody. The reaction with anti-human TeBG antibody appeared to be localized in the epithelial cells of the original and metastatic tissues of the prostate, and a weakly positive stain also appeared in parenchymal liver cells. The staining of the epithelial cancer cells with anti-human TeBG antibody was uneven, suggesting that the hormone-independent cancer cell population is heterogeneous as far as the localization of the TeBG is concerned.Keywords
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