A COMPARISON OF STEROID PRODUCTION IN VITRO AND IN VIVO BY THE ADRENAL GLAND OF THE RAT

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Abstract
SUMMARY: The major steroid products of the rat adrenal gland were studied both in vitro and in vivo. It was found that these methods gave similar results with regard both to the nature of the compounds produced and to their relative proportions. In particular, the status of 11-desoxycorticosterone as a physiologically important adrenal product is discussed, and it is concluded that this compound, as well as aldosterone, may possibly be instrumental in controlling electrolyte flux in the rat.