Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys

This publication has 45 references indexed in Scilit:

• Role of IL–5 in the Development of Allergen–Induced Airway Hyperresponsiveness
  International Archives of Allergy and Immunology, 1999
• Biology of IL-5 in health and disease
  Annals of Allergy, Asthma & Immunology, 1999
• Humanized Antibodies as Potential Therapeutic Drugs
  Annals of Allergy, Asthma & Immunology, 1998
• Interleukin‐5 and eosinophils induce airway damage and bronchial hyperreactivity during allergic airway inflammation in BALB/c mice
  Immunology & Cell Biology, 1997
• IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses
  Published by Elsevier ,1996
• Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
  The Journal of Experimental Medicine, 1996
• Sorting out the cytokines of asthma.
  The Journal of Experimental Medicine, 1996
• Changes in the phenotypic characteristics of eosinophils from patients receiving recombinant human interleukin‐2 (rhIL‐2) therapy
  British Journal of Haematology, 1994
• Recombinant Human Soluble CD4 Does Not Inhibit Immune Function in Cynomolgus Monkeys
  Toxicologic Pathology, 1991
• Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophilsin vitro
  Clinical and Experimental Immunology, 1991