ALPHA-FETOPROTEIN AND OTHER SERUM-PROTEINS SYNTHESIZED BY ENDODERMAL SINUS TUMOR TRANSPLANTED INTO NUDE-MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 71  (1) , 14-17
Abstract
The human yolk sac synthesizes .alpha.-fetoprotein and other serum proteins, i.e., albumin, prealbumin, .alpha.1-antitrypsin and transferrin. Two endodermal sinus tumors (yolk sac tumors) were successfully transplanted into nude mice. Concentration of these human serum proteins in the sera of the nude mice and tumor extracts were determined quantitatively by electro-immunodiffusion and radioimmunoassay. .alpha.-Fetoprotein and albumin were detected in one case, .alpha.1-antitrypsin and .alpha.-fetoprotein in the other. In the former case, the amount of .alpha.-fetoprotein synthesized was larger than that of albumin, the amount of .alpha.-fetoprotein was smaller than that of .alpha.1-antitrypsin in the latter. Human endodermal sinus tumors may simulate the human yolk sac functionally, but the pattern of protein synthesis may differ from case to case.

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