The immunopharamacologic and anti-inflammatory properties of RMI 9563 with special reference to its effect on the complement system
- 1 April 1978
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 8 (3) , 218-228
- https://doi.org/10.1007/bf01966607
Abstract
The immunopharmacology of RMI 9563 — bis[3-(diethylamino)propyl]fluoranthene-3,9-dicarboxylate dihydrochloride — has been described. The compound, when given parenterally, inhibited several cell-mediated immune responses (EAE, tuberculin skin reaction, adjuvant arthritis) in rats, enhanced IgM and IgG antibody-producing cells in mice, and displayed anti-inflammatory activity in several models (carrageenan paw edema, adjuvant arthritis, direct passive Arthus reaction — a model of inflammation that is immunologically induced and complement-dependent). RMI 9563 suppressed the activation of complement in vitro by the selective inhibition of C1 esterase.This publication has 30 references indexed in Scilit:
- Study of lymphoid cells from inflamed synovial membranes.Annals of the Rheumatic Diseases, 1975
- ComplementAnnual Review of Biochemistry, 1975
- LYMPHOKINES IN RHEUMATOID SYNOVITISAnnals of the New York Academy of Sciences, 1975
- Studies on synovial fluid lymphocytes in rheumatoid arthritis.Annals of the Rheumatic Diseases, 1974
- Hypocomplementemia in Rheumatoid ArthritisArthritis & Rheumatism, 1971
- DEPRESSION OF SYNOVIAL FLUID COMPLEMENT ACTIVITY AND RHEUMATOID FACTOR POSITIVITYActa Medica Scandinavica, 1970
- Irreversible enzyme inhibitors. CLII. Proteolytic enzymes. 10. Inhibition of guinea pig complement by substituted benzamidinesJournal of Medicinal Chemistry, 1969
- IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICEThe Journal of Experimental Medicine, 1967
- The arthus phenomenon — A mechanism of tissue damageArthritis & Rheumatism, 1967
- Passive Transfer of Adjuvant Arthritis in Rats with Living Lymphoid Cells of Sensitized DonorsInternational Archives of Allergy and Immunology, 1963