Orally Given Combinations of Drugs in Diabetes Mellitus Therapy

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Abstract
A total of 25 ambulatory diabetic patients were treated with a combination of phenformin (DBI) and a sulfonylurea drug (either tolbutamide or chlorpropamide). These patients had failed to respond fully to treatment with a sulfonylurea drug alone. The therapy was successful in reducing blood sugar to satisfactory levels in 19 patients, but 3 discontinued the treatment because of gastrointestinal intolerance. The therapy was unsuccessful in six patients, owing to the severity of the diabetes. The use of a combination of drugs increases the percentage of diabetic patients for whom oral therapy is applicable and decreases the incidence of side effects.

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