Requirement of Tissue-Selective TBP-Associated Factor TAF II 105 in Ovarian Development
- 14 September 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5537) , 2084-2087
- https://doi.org/10.1126/science.1061935
Abstract
Transcription factor TFIID, composed of TBP and TAFIIsubunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type–specific component of the mammalian transcriptional machinery.Keywords
This publication has 20 references indexed in Scilit:
- Spermiogenesis Deficiency in Mice Lacking the Trf2 GeneScience, 2001
- Distinct Roles for TBP and TBP-Like Factor in Early Embryonic Gene Transcription in XenopusScience, 2000
- Specific Interaction of TAFII105 with OCA-B Is Involved in Activation of Octamer-dependent TranscriptionJournal of Biological Chemistry, 2000
- Identification of Two Novel TAF Subunits of the YeastSaccharomyces cerevisiae TFIID ComplexJournal of Biological Chemistry, 2000
- Mouse models of ovarian failureReviews of Reproduction, 1998
- Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells.Genes & Development, 1997
- Roles of Inhibins, Activins, and Follistatin in the Female Reproductive SystemFrontiers in Neuroendocrinology, 1996
- Drosophila TAF II 150: Similarity to Yeast Gene TSM-1 and Specific Binding to Core Promoter DNAScience, 1994
- Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIBCell, 1993
- Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivatorsCell, 1993