Necrosis and Inhibition of Growth of Human Lung Tumor by Anti-α-Human Chorionic Gonadotropin Antibody

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Abstract
Human lung tumor cells (ChaGo) established in culture from a broncho-genie squamous cell carcinoma synthesize and secrete large amouts of human chorionic gonadotropin (HCG), predominatly the α subunit of the gly-coprotein hormone. ChaGo cells lose their transformation phenotypes following treatment with antiα-HCG antibody or following inhibition of intracellular synthesis of α-HCG by the anti-sense RNA technique. We report that tumors induced by ChaGo cells in female athymic mice undergo necortic degeneration following local of intra peritoneal administration of α-HCG-specific-antibody. The α-HCG antibody did not affect the growth of tumors induced by α-HCG nonproducing human tumor cells. Histopathological examinations of the anti-αHCG antibody-treated tumor tissues showed active necrosis. When the antibody treatment was discontinued, the tumorigenesis process resumed. When antiα-HCG antibody was administered simultaneously with ChaGo cells, a concentration-dependent inhibition of tumor growth in athymic mice was completely prevented at higher concentrations of the specific antibody. [J Natl Cancer Inst 84: 42–47, 1992]

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