CELL-MEDIATED LYMPHOCYTOTOXICITY DIRECTED AGAINST HLA-D GENE PRODUCTS

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Abstract
Cytotoxic effector cells were generated in human mixed lymphocyte cultures (MLC) between cell donors differing at the HLA-D/DR region but not at HLA-A,B(C). These cells killed Epstein-Barr virus-infected lymphoblasts (EBV blasts) from donors sharing the HLA-D/DR determinants with the normal MLC-stimulating cells but not phytohemagglutinin (PHA) lymphoblasts from the same donors. EBV blasts are derived from B [bone marrow-derived] cells and express HLA-D/DR antigens; the HLA-D/DR antigens may, by themselves, act as targets for cell-mediated cytotoxicity.

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