EXCHANGE OF SUBSTANCES IN AQUEOUS SOLUTION BETWEEN JOINTS AND THE VASCULAR SYSTEM 123

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Abstract
The present series of expts. was undertaken to examine the manner of removal of materials of small molecular dimensions, present in homogeneous aq. solns. from normal joints and from joints in certain induced pathological states. Solns. containing a drug having a powerful effect on the blood pressure were selected because they offered a ready and continuous means of observing their transference from joint cavity to blood stream. The effect of mecholyl (acetyl-beta-methylcholine chloride), was observed in 30 to 60 secs. after inj. into a joint. Passive exercise and induced inflammation of a joint enhanced absorption. The rapidity of absorption, and its inhibition by subsequent intra-articular inj. of adrenaline, suggested that the absorption was via the blood capillaries. Intra-articular inj. of pituitrin and pilo-carpine also led to prompt systemic effects. In 2 of 9 expts. done on eserinized cats, a small amt. of vasodepressor substance was detected in thoracic duct lymph 45 and 60 mins., respectively, after intra-articular inj. of mecholyl. The blood-vascular interchange was interpreted as being of primary importance in the acute changes in the vol. and in the electrolytes of synovial fluid.

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