An Experimental Study on the Origin of T-Waves Based on Determinations of Effective Refractory Period from Epicardial and Endocardial Aspects of the Ventricle

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Abstract
The effective refractory period was determined at the surface and in the deeper layers of the dog heart and was correlated with the surface T-waves. A small delay in recovery of cardiac excitability appeared at the surface when T-waves were negative and in the deeper layers when T-waves were positive. Acute injury produced by ligation of the coronary artery caused a marked acceleration of recovery in the deeper layers, sometimes extending to the surface.

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