Determination of Serum and Urine Concentrations of Tranylcypromine by Electron-Capture Gas-Liquid Chromatography
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 1 (5) , 215-217
- https://doi.org/10.1093/jat/1.5.215
Abstract
A method is presented for the gas-liquid chromatographic determination of tranylcypromine in serum and urine at therapeutic concentrations. Both the drug and the internal standard are converted to trichloroacetyl derivatives and are assayed using electron-capture detection. Following ingestion of 30 mg of tranylcypromine sulfate, peak serum concentrations averaged 39 ng/ml in two volunteers with less than 2% of the dose excreted unchanged in the 24-hour urine.This publication has 3 references indexed in Scilit:
- Tranylcypromine Concentrations and Monoamine Oxidase Activity in Tissues from a Fatal PoisoningJournal of Analytical Toxicology, 1977
- Influence of Urinary pH on the Excretion of Tranylcypromine SulphateNature, 1967
- Metabolism of Tranylcypromine-C14 and dl-Amphetamine-C14 in the RatJournal of Medicinal Chemistry, 1963