Some Changes in Metabolism Due to Acidosis in Shock

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Abstract
The glycolytic activity of erythrocytes and rat diaphragms from animals in shock with acidosis was followed in vitro. The utilization of glucose by erythrocytes and by diaphragms of animals in shock drops with decreasing pH of the blood. The drop is proportional to the decrease in the pH of the blood. The correction of acidobasic balance cancels in the lowered glycolysis caused by acidosis both in vitro and in vivo. In erythrocytes lower values of adenosine triphosphate (ATP) were found in shock and after incubation at a lower pH. With erythrocytes incubated at pH 7.5, the level of ATP increases to normal values.

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