Quantitation of Chloroquine Phosphate And Primaquine Phosphate In Tablets Using High-performance Liquid Chromatography
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 19 (13-14) , 1523-1532
- https://doi.org/10.1080/00032718608069123
Abstract
Reverse phase high-performance liquid chromatography methods for the quantitation of chloroquine phosphate and primaquine phosphate in tablets have been developed. The methods require one column and 2 mobile phases for complete analysis of both drugs when present in combination. The methods are accurate and precise with percent relative standard deviations based on 6 injections of 0.5 and 0.9 for chloroquine and primaquine, respectively. The results of single ingredient, chloroquine phosphate tablets are in excellent agreement with the USP-NF method which is nonspecific. Primaquine interfers with the USP-NF method and not with the developed HPLC method. Both drugs appear to be very stable to heat.Keywords
This publication has 1 reference indexed in Scilit:
- THE ESTIMATION OF BASIC ORGANIC COMPOUNDS IN BIOLOGICAL MATERIALPublished by Elsevier ,1947