MINIMUM OVULATION INHIBITORY LEVELS OF ETHINYL ŒSTRADIOL

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Abstract
In a series of 86 women in whom ovulation was suppressed with ethinyl œstradiol in a dosage of 0.05 mg given for 25 days from the first day of menstruation, the interval between courses of medication was increased until ovulation occurred. Six per cent ovulated with an interval of five days, 36% with an interval of seven days, 65% with an interval of nine days, 90% with an interval of 11 days, and 97% with an interval of 13 days. After medication was stopped, an average of 14 days elapsed before ovulation occurred. In some subjects it was necessary to commence medication only three or four days before the anticipated day of ovulation in order to suppress ovulation. In others, it was necessary to administer the oestrogen for 12 to 14 days before the expected time of ovulation in order to prevent ovulation. On the average, it was necessary to commence medication a week before the expected time of ovulation in order to inhibit ovulation.

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