SERUM GLUTAMIC OXALACETIC TRANSAMINASE (SGO-T) IN CONGESTIVE HEART FAILURE: CLINICAL STUDY AND REVIEW OF THE LITERATURE

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Abstract
Considerable confusion has arisen in the interpretation of SGO-T levels in congestive heart failure. A review of case records of 43 patients with acute congestive heart failure with SGO-T determinations revealed elevated levels in 13 cases. One patient with chronic pulmonary emphysema and right heart failure with an SGO-T titer of 515 units is presented in detail. A review of the literature disclosed 25% of reported cases to have elevated SGO-T values up to 3000 units. A group of 15 patients with chronic congestive heart failure followed in a cardiac clinic had normal SGO-T titers. It appears that the SGO-T level is often elevated markedly in patients with acute congestive heart failure or an acute exacerbation of chronic congestive failure. This fact applied in cases of left, right or combined congestive failure. The highest SGO-T values were found in chronic lung disease with secondary right heart failure. Hepatic tissue, when obtained by biopsy or at postmortem examination, showed varying degrees of centrilobular necrosis.