Bronchodilating Plasma Concentrations of Enprofylline and Theophylline have Minor Cardiovascular Effects in Man

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Abstract
The cardiovascular effects with bronchodilating plasma concentration of theophylline (3.8-12.6 mg/l) and enprofylline (0.8-3.0 mg/l) were studied in six healthy male subjects by means of non-invasive procedures. With these plasma concentrations only minor effects were noted with regard to heart rate, blood pressure and systolic time intervals. However, both xanthines seem to have a vasodilating ability and a weak positive inotropic effect on the heart.