The AED (Antiepileptic Drug) Pregnancy Registry

Abstract
Pregnancy registries have been developed to provide an early signal of an increased frequency of major malformations associated with prenatal exposure to the products monitored by the registry.1 The first such registry, developed by Andrews and her associates2,3 at Burroughs Wellcome in 1984, enrolled pregnant women who had taken the antiviral drug acyclovir. Subsequent company-based registries have focused on drugs4 and vaccines.5