Foamy virus vectors
- 1 January 1996
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 70 (1) , 217-222
- https://doi.org/10.1128/jvi.70.1.217-222.1996
Abstract
Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.Keywords
This publication has 0 references indexed in Scilit: