Metabolic response to a pantothenic acid deficient diet in humans.

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Abstract
The responses of human subjects to a low pantothenic acid test diet and to the same diet supplemented with 10 mg pantothenic acid daily for 63 days were observed. Pantothenic acid in urine and blood and also N balance were used as criteria for nutritional evaluation. The mean daily urinary pantothenic acid excretion decreased from 3.05 to 0.79 mg in male adult subjects fed a pantothenic acid deficient diet and increased from 3.95 to 5.84 mg in 4 subjects fed a 10 mg supplemented diet from the beginning to the end of 63 day study. A test dose of 100 mg of pantothenic acid was given to both groups for a 7 day period. Subjects previously deprived of pantothenic acid retained 63% of the test dose on the 1st day of the test period in contrast to 48% retained by supplemented subjects. On the 7th day, both groups retained approximately 40% of the dose. While blood pantothenic acid levels decreased in unsupplemented subjects and remained constant in supplemented subjects, blood pantothenic acid responded less readily to intake than urinary pantothenic acid. N retention tended to be higher in supplemented subjects than in those deprived of dietary pantothenic acid.

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